Table 3.
Quantile (median) regression analysis of pneumococcal density in ten-valent pneumococcal conjugate vaccine (PCV10) vaccinated and unvaccinated children aged 12–23 months who were pneumococcal carriers (n=848)
| Number of carriers | Median density* | Adjusted coefficient†(95% CI) | p value | Pseudo-R2 value | |
|---|---|---|---|---|---|
| Overall pneumococci | |||||
| Unvaccinated | 485 | 5·16 | Reference | 0·0004 | 0·031 |
| PCV10-vaccinated | 363 | 4·85 | −0·39 (−0·61 to −0·18) | .. | .. |
| PCV10 serotypes | |||||
| Unvaccinated | 207 | 5·16 | Reference | 0·0077 | 0·064 |
| PCV10-vaccinated | 72 | 4·45 | −0·56 (−0·98 to −0·15) | .. | .. |
| Non-PCV10 serotypes | |||||
| Unvaccinated | 331 | 5·03 | Reference | 0·0334 | 0·018 |
| PCV10-vaccinated | 312 | 4·86 | −0·29 (−0·57 to −0·02) | .. | .. |
Data are from all four years combined. PCV10-vaccinated=received one or more doses of PCV10 vaccine.
*
Density reported in log10 genome equivalents per mL.
†
Coefficient is the difference in medians as determined by quantile regression, adjusted for upper respiratory tract infection symptoms, poverty, and two or more children younger than 5 years in the household.