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. 2018 Oct 29;2018:9179270. doi: 10.1155/2018/9179270

Figure 2.

Figure 2

Effects of resveratrol on mitophagy, autophagy, and ROS levels in the muscle of mdx mice. (a) Expression levels of mitophagy- and autophagy-related genes in the quadriceps muscle from untreated mdx mice and mdx mice treated with resveratrol (RSV) at 0.04, 0.4, and 4 g/kg food (RSV-0.04, RSV-0.4, and RSV-4, respectively). n = 4 in each group. (b) Western blot analysis for ubiquitinated proteins in the quadriceps. (c) Representative Western blots for LC3 in the muscle tissue (left) and summary data of the LC3-II/LC3-I ratio (right). n = 4 in each group. (d) Representative Western blot for p62 in muscle (left) and summary data of p62 normalized to the GAPDH level (right). n = 4 in each group. (e) Representative dihydroethidium (DHE) staining in the quadriceps (upper) and summary data of DHE fluorescence intensity (lower). Six randomly selected images were captured in each muscle section, and 4 mice were analyzed in each group. Scale bar: 50 μm. ∗ P < 0.05; ∗∗ P < 0.01. NS: not significant.