Figure 3.

Resveratrol decreases muscular injury and improves muscle function in mdx mice. (a) Representative images of the quadriceps stained with FITC-conjugated wheat germ agglutinin (WGA, green) and Hoechst 33342 (blue) to detect myofiber membranes and nuclei, respectively. Muscle sections were obtained from untreated and resveratrol-treated mdx mice. Scale bar: 50 μm. (b) Percentage of myofibers with central nuclei in mdx mice. n = 4 in each group. (c) Cross-sectional area of myofibers in the quadriceps muscles in mdx mice. n = 4 mice per group. (d, e) Serum levels of the muscle isoform of creatine kinase (CK-MM) in the mdx mice at 23 (d) and 65 weeks old (e). n = 5–6 mice per group. (f) Hanging time assessed by the inverted hang test of mdx mice at 37 weeks of age. (g) Rotarod riding time in mdx mice at 40 weeks of age. n = 4–5 mice per group. ^∗ P < 0.05; ^∗∗ P < 0.01.