Figure 2.

(a) Sequenom EpiTYPER system analysis of the average methylation ratio of APC2 in CRC tissues, ^∗p < 0.05. (b) Representative APC2 methylation levels between the tumor and adjacent tissue samples using BSP PCR-based sequencing analysis. Methylation levels in the tumor samples were higher than in the adjacent samples. Each row represents an individually sequenced clone and each column square, a CpG residue. White and black squares represent unmethylated and methylated cytosines, respectively (p < 0.05).