Table 2.
Demographic data for participants in APOE ε4 versus APOE non-ε4 analysis.
| Study | Study Characteristics |
N |
Age |
Sex |
Education |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ε4 | non-ε4 | ε4 |
non-ε4 |
ε4 | non-ε4 | ε4 |
non-ε4 |
Education Metric | |||||||
| Recruitment Age Range | Genotype Breakdown | M | SD | M | SD | %F | %F | M | SD | M | SD | ||||
| Alexopoulos et al. (2011) | College-aged | ε2/2, ε2/3 vs. ε3/4, ε4/4 | 16 | 17 | 24.20 | 4.10 | 24.70 | 3.20 | 56% | 71% | 16.56 | 2.07 | 17.35 | 2.69 | Years |
| Bloss et al. (2008) −familyhxa | 11-16 | ε2/3, 3/3 vs. ε3/4, ε4/4 | 24 | 85 | 13.42 | 1.40 | 13.42 | 1.22 | 50% | 56% | 16.46 | 2.17 | 16.35 | 2.09 | Mother-years |
| Bloss et al. (2008) +familyhxa | 11-16 | ε2/3, 3/3 vs. ε3/4, ε4/4 | 24 | 85 | 13.42 | 1.40 | 13.42 | 1.22 | 50% | 56% | 16.46 | 2.17 | 16.35 | 2.09 | Mother-years |
| Bloss et al. (2010) | 11-16 | ε3/3 vs. ε3/4, ε4/4 | 33 | 90 | 13.34 | 1.32 | 13.28 | 1.30 | 55% | 61% | 16.46 | 2.17 | 16.28 | 2.15 | Mother-years |
| Bunce et al. (2011) | 20-24 | ε3/3 vs. ε3/4, ε4/4 | 530 | 1291 | (20-24) | – | (20-24) | – | 50% | 53% | 14.56 | 1.59 | 14.56 | 1.55 | Years |
| Bunce et al. (2014) | 20-24 | ε2/2, ε2/3 vs. ε3/4, ε4/4 | 426 | 189 | (20-24) | – | (20-24) | – | – | – | – | – | – | – | – |
| Calderon-Garciduenas et al. (2016) Femalea | Children | ε3/3 vs. ε3/4 | 36 | 69 | 12.70 | 6.70 | 11.89 | 4.10 | 53% | 43% | 11.62 | 1.90 | 11.07 | 2.30 | Mother-years |
| Calderon-Garciduenas et al. (2016) Malesa | Children | ε3/3 vs. ε3/4 | 36 | 69 | 12.70 | 6.70 | 11.89 | 4.10 | 53% | 43% | 11.62 | 1.90 | 11.07 | 2.30 | Mother-years |
| Calderon-Garciduenas et al. (2015)) | Children | ε3/3 vs. ε3/4, ε4/4 | 22 | 28 | 13.62 | 4.80 | 13.36 | 5.00 | 50% | 43% | 11.62 | 1.74 | 11.07 | 2.12 | Mother-years |
| Dell’Acqua et al., 2015 | 14 year olds | ε3/3 vs. ε3/4 | 114 | 372 | 14.40 | 0.50 | 14.40 | 0.50 | 41% | 45% | – | – | – | – | – |
| Dennis et al. (2010) | Young Adult | ε2/3, ε3/3 vs. ε3/4, ε4/4 | 12 | 12 | 21.80 | 3.30 | 20.80 | 2.90 | 58% | 75% | – | – | – | – | – |
| Dowell et al. (2013) | 18-30 | ε3/3 vs. ε3/4, ε4/4 | 21 | 20 | 21.40 | 2.20 | 20.90 | 1.40 | 62% | 70% | – | – | – | – | – |
| Evans et al. (2014) | 18-30 | ε3/3 vs. ε3/4, ε4/4 | 21 | 20 | 21.40 | 2.20 | 20.90 | 1.40 | 62% | 70% | 15.10 | 0.20 | 15.10 | 0.30 | Years |
| Filippini et al. (2009) | 20-35 | ε3/3 vs. ε3/4, ε4/4 | 18 | 18 | 28.40 | 4.90 | 28.60 | 3.90 | 39% | 44% | 19.60 | 2.00 | 19.50 | 1.50 | Years |
| Green et al. (2014) CLU-C sampleb | College-aged | ε3/3 vs. ε3/4, ε4/4 | 23 | 16 | 24.00 | 5.49 | 25.25 | 5.87 | 17% | 6% | – | – | – | – | – |
| Jorm et al. (2007) | 20-24 | ε2/3, ε3/3 vs. ε3/4 | 517 | 1524 | (20-24) | – | (20-24) | – | – | – | – | – | – | – | – |
| Kunz et al. (2015) | 18-30 | ε3/3 vs. ε3/4 | 38 | 37 | 22.34 | 0.45 | 22.76 | 0.49 | 53% | 51% | 16.05 | 0.37 | 16.19 | 0.38 | Years |
| Matura et al. (2016) | 20-39 | ε3/3 vs. ε3/4, ε4/4 | 25 | 25 | 26.75 | 5.31 | 25.83 | 3.61 | 44% | 44% | 17.67 | 2.12 | 17.58 | 2.43 | Years |
| Matura et al. (2014) | 20-38 | ε3/3 vs. ε3/4, ε4/4 | 25 | 25 | 26.60 | 5.20 | 26.20 | 4.10 | 44% | 44% | 17.70 | 2.10 | 17.60 | 2.60 | Years |
| Mondadori et al. (2007) | Young Adult | ε2/3, ε3/3 vs. ε3/4, ε4/4 | 13 | 10 | 22.60 | 3.50 | 21.60 | 1.70 | 46% | 60% | 14.30 | 1.70 | 13.80 | 1.50 | Years |
| Ng et al. (2013) High Mercuryc | Age 2 | ε3/3 vs. ε3/4, ε4/4 | 14 | 59 | 2.00 | 0.00 | 2.00 | 0.00 | 50% | 39% | 50% | – | 57.6% | – | Mother %college edu |
| Ng et al. (2013) Low Mercuryc | Age 2 | ε3/3 vs. ε3/4, ε4/4 | 12 | 51 | 2.00 | 0.00 | 2.00 | 0.00 | 67% | 49% | 50% | – | 56.9% | – | Mother %college edu |
| Nichols et al. (2012) scanned cohort | 19-40 | ε3/3 vs. ε3/4 | 23 | 57 | 27.00 | 4.90 | 27.00 | 5.30 | 40% | 58% | 17.00 | 1.50 | 17.00 | 2.40 | Years |
| Nichols et al. (2012) non-scanned cohort | 18-40 | ε3/3 vs. ε3/4 | 48 | 122 | (18-40) | – | (18-40) | – | 67% | 54% | – | – | – | – | – |
| O’Dwyer et al. (2012) | 20-38 | ε3/3 vs. ε3/4, ε4/4 | 22 | 22 | 26.90 | 5.30 | 26.70 | 4.00 | 41% | 41% | 17.00 | 4.30 | 16.80 | 4.50 | Years |
| Reiman et al. (2004) | 20-39 | ε2/3, ε3/3 vs. ε3/4 | 12 | 15 | 30.70 | 5.40 | 31.20 | 5.00 | 75% | 80% | 16.00 | 1.70 | 16.10 | 1.50 | Years |
| Ruiz et al. (2010) | 13-18.5 | ε2/3, ε3/3 vs. ε3/4 | 76 | 336 | NA | NA | NA | NA | 49% | 51% | – | – | – | – | – |
| Shaw et al. (2007) | < 21yo | ε3/3 vs. ε3/4, ε4/4 | 65 | 145 | NA | NA | NA | NA | 51% | 42% | – | – | – | – | – |
| Sinclair et al. (2015) | 18 | ε3/3 vs. ε3/4 | 542 | 1215 | 18.00 | 0.00 | 18.00 | 0.00 | 51% | 56% | 23.2% | – | 20.9% | – | Mother % w/ degree |
| Stening et al. (2016) Female | 19-35 | ε3/3 vs. ε3/4, ε4/4 | 16 | 39 | 23.20 | 3.20 | 23.60 | 3.60 | 100% | 100% | 14.60 | 1.90 | 14.80 | 1.90 | Years |
| Stening et al. (2016) Male | 19-35 | ε3/3 vs. ε3/4, ε4/4 | 19 | 36 | 25.30 | 3.90 | 23.60 | 2.80 | 0% | 0% | 16.10 | 1.80 | 14.70 | 1.30 | Years |
| Suri et al. (2015) | 20-40 | ε3/3 vs. ε3/4, ε4/4 | 18 | 17 | 23.88 | 4.75 | 24.11 | 4.96 | 56% | 53% | 17.05 | 2.18 | 17.50 | 2.89 | Years |
| Wierenga et al. (2013) | College-aged | ε3/3 vs. ε3/4, ε4/4 | 15 | 15 | 23.60 | 3.10 | 23.30 | 3.00 | 80% | 53% | 14.90 | 0.30 | 15.00 | 0.50 | Years |
| Zhang et al. (2015) | 16-39 | ε3/3 vs. ε3/4, ε4/4 | 47 | 200 | 26.90 | 5.90 | 27.44 | 6.40 | 55% | 47% | 11.30 | 3.75 | 11.02 | 3.59 | Years |
Note: n = study sample size; sd = standard deviation, M = mean, edu = education, %F = percent female; ε4= at least one Apolipoprotein ε4 allele; non-ε4 = Apolipoprotein ε2 and/or ε3 carriers.
a
Study reports cognitive data separately by subgroup but demographics are reported for full sample.
b
Study examines CLU-C and non-CLU-C; only CLU-C was considered because CLU-nonC ε4 group only included three participants.
c
Study of toddlers who were exposed to mercury while in the womb.