Table 4.

Case-control analyses for family history of cancer stratified by oophorectomy indication (all ages).

	Benign Indication							No Ovarian Indication
Cancer Type	Bilateral Oophorectomy (n=675)			Control Women (n=675)		Adjusted Odds Ratio (95% Cl)a	p Value	Bilateral Oophorectomy (n=978)			Control Women (n=978)		Adjusted Odds Ratio (95% Cl)a	p Value
	N	%		N	%			N	%		N	%
Breast
Noneb	531	78.7		536	79.4	1.00 (reference)	--	762	77.9		766	78.3	1.00 (reference)	--
First degree	85	12.6		84	12.4	0.99(0.72, 1.38)	0.98	140	14.3		145	14.8	0.94(0.73, 1.21)	0.65
Other relative	59	8.7		55	8.1	1.16(0.79, 1.72)	0.45	76	7.8		67	6.9	1.10(0.78, 1.54)	0.59
Ovarian
Noneb	622	92.1		645	95.6	1.00 (reference)	--	905	92.5		927	94.8	1.00 (reference)	--
First degree	33	4.9		16	2.4	1.89(1.03, 3.48)	0.04	46	4.7		36	3.7	1.27(0.81, 1.99)	0.30
Other relative	20	3.0		14	2.1	1.24(0.62, 2.48)	0.55	27	2.8		15	1.5	1.81 (0.96,3.41)	0.07
Uterine
Noneb	651	96.4		636	94.2	1.00 (reference)	--	916	93.7		939	96.0	1.00 (reference)	--
First degree	14	2.1		35	5.2	0.39(0.21, 0.72)	0.003	50	5.1		28	2.9	1.83(1.15,2.92)	0.01
Other relative	10	1.5		4	0.6	2.25 (0.67, 7.54)	0.19	12	1.2		11	1.1	1.12(0.49,2.55)	0.79
Other cancers by relative (any other type)
Noneb	416	61.6		500	74.1	1.00 (reference)	--	637	65.1		690	70.6	1.00 (reference)	--
First degree	176	26.1		114	16.9	1.76(1.34, 2.31)	<0.001	247	25.3		194	19.8	1.30(1.06, 1.61)	0.01
Other relative	83	12.3		61	9.0	1.47(1.02, 2.11)	0.04	94	9.6		94	9.6	1.02(0.75, 1.37)	0.92
Other cancers by type (any relative)
Other gynecologicc	7	1.0		3	0.4	2.16(0.55, 8.48)	0.27	8	0.8		5	0.5	1.58(0.51,4.86)	0.43
Male specificd	38	5.6		38	5.6	0.94(0.58, 1.52)	0.79	53	5.4		49	5.0	1.04(0.70, 1.56)	0.84
Lung	53	7.9		36	5.3	1.41 (0.90, 2.19)	0.13	72	7.4		54	5.5	1.36(0.95, 1.96)	0.10
Kidney	8	1.2		0	0.0	--	--	3	0.3		9	0.9	0.32(0.09, 1.19)	0.09
Liver or biliary duct	11	1.6		12	1.8	0.96(0.42, 2.21)	0.93	14	1.4		7	0.7	1.99(0.80,4.94)	0.14
Colorectal	83	12.3		41	6.1	2.26(1.51, 3.39)	<0.001	92	9.4		90	9.2	1.00(0.74, 1.35)	1.00
Other gastrointestinale	10	1.5		11	1.6	0.85(0.34, 2.13)	0.73	16	1.6		27	2.8	0.61 (0.33, 1.14)	0.12
Pancreas	10	1.5		11	1.6	0.94(0.39, 2.26)	0.89	18	1.8		12	1.2	1.44(0.69,3.01)	0.33
Hematologicf	16	2.4		26	3.9	0.63(0.34, 1.20)	0.16	50	5.1		34	3.5	1.46(0.94,2.28)	0.09
Sking	31	4.6		23	3.4	1.32(0.76, 2.29)	0.32	36	3.7		37	3.8	0.94(0.59, 1.50)	0.81
Miscellaneoush	31	4.6		22	3.3	1.36(0.77, 2.41)	0.29	52	5.3		38	3.9	1.31 (0.85,2.02)	0.23
Unknown type	19	2.8		12	1.8	1.38(0.66, 2.88)	0.39	8	0.8		11	1.1	0.68(0.27, 1.72)	0.42

^aThe odds ratios and confidence intervals for each cancer were calculated using conditional logistic regression models (matched pairs) adjusted for years of education (≤12; 13–16; >16), race (white; non-white), and quartiles of household income (<$42,000; $42,000–56,999; $57,000–71,999; ≥$72,000). Women with unknown education (3 cases with benign indication and 15 controls; 0 cases with no ovarian indication and 20 controls) were assigned to the ≤12 years group, and women with unknown income (3 cases with benign indication and 2 controls; 3 cases with no ovarian indication and 0 controls) were assigned to the $42,000–56,999 group (second quartile).

^bIncludes women with unknown family history of cancer (14 cases with benign indication and 0 controls; 4 cases with no ovarian indication and 3 controls).

^cCervical, fallopian tube, or vulvar cancer.

^dProstate or testicular cancer.

^eAppendix, esophageal, or stomach cancer.

^fLeukemia, lymphoma or myeloma.

^gMelanoma or non-melanoma skin cancer.

^hBladder, bone, brain, oral, thyroid, or other types of cancer.