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. 2018 Nov 8;11:2797–2808. doi: 10.2147/JPR.S171664

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© 2018 Yuan et al. This work is published and licensed by Dove Medical Press Limited

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Comparison of the effects of EA on pain hypersensitivity in wild-type mice and CB2^−/− mice subjected to KOA induction.

Notes: Time course of changes in the tactile threshold in the wild-type mice (A) and CB2^−/− mice (B) after KOA induction. Time course of changes in the thermal withdrawal threshold in the wild-type mice (C) and CB2^−/− mice (D) after KOA induction. Effects of KOA and EA on weight bearing of wild-type mice (E) and CB2^−/− mice (F) subjected to KOA induction. EA was administered for 30 minutes, once every other day for 4 weeks, starting from 2 days after MIA injection, as indicated by arrows. Data are expressed as mean±SD (n=8 mice in each group). *P<0.05, compared with the control group; ^#P<0.05, compared with the KOA group.

Abbreviations: CON, control; EA, electroacupuncture; KOA, knee osteoarthritis; MIA, monosodium iodoacetate.