Figure 6.
Thermal imaging and anti-tumor efficacy of PTT in vivo for 4T1 xenograft tumor mice.
Notes: (A) Representative thermal images of tumor under irradiation laser (0.2 W/cm2, 10 minutes) after treatment with CuS NPs and CuS-Ab NPs. (B) Rising temperature curve of tumor in live mice after treatment with CuS NPs and CuS-Ab NPs. The control group was treated with PBS. (C) The weight of the mice was monitored every other day. (D) Tumor volume curve of xenograft tumor mice over 2 weeks. The tumor volume was calculated from the length and width of the tumor, obtained from live mice every other day. (E) Representative tumor images were obtained from live mice in different groups with or without treatment. (F) Immunohistochemistry staining of CD31 in tumor. The red arrow indicates CD31 in endothelial vessels. All data represent mean values (n=6). **P<0.01.
Abbreviations: CuS NP, CuS nanoparticle; CuS-Ab NP, cetuximab-modified CuS NP; PTT, photothermal therapy.