Table 1.
Peripheral and brain S100B levels
| A: Maximal estimated contribution to peripheral S100B from the brain and extracranial sources (based on the study by Dadas et al78)
| |||||
|---|---|---|---|---|---|
| Volume of organ (cm3) | S100B (ng/mg) | Estimated S100B (ng) | % of CNS total | Maximum S100B serum levels (ng/mL) | |
| Liver | 1,690 | 1 | 2,113 | 0.02 | 0.01 |
| Kidney | 280 | 0 | 70 | 0.00 | 0.00 |
| Lung | 1,172 | 4 | 4,395 | 0.03 | 0.02 |
| Muscle | 35,000 | 3 | 105,000 | 0.79 | 0.43 |
| Pancreas | 77 | 2 | 154 | 0.00 | 0.00 |
| Fat | 10,000 | 5 | 54,600 | 0.41 | 0.22 |
| Brain | 1,400 | 96 | 133,700 | 1.00 | 0.55 |
| Stomach | 154 | 3 | 462 | 0.00 | 0.00 |
| Skin | 7,800 | 3 | 21,450 | 0.16 | 0.09 |
| B: Contribution of CNS and peripheral sources to S100B levels | |||
| Extracranial | Breast | Myoepithelial cells | 10 |
| Neural tissue | Caudate | Glial cells | 10 |
| Neural tissue | Cerebellum | 10 | |
| Neural tissue | Cerebral cortex | Glial cells | 10 |
| Neural tissue | Cerebral cortex | Neuropil | 10 |
| Neural tissue | Hippocampus | Glial cells | 10 |
| Extracranial | Skin | Langerhans | 10 |
| Extracranial | Peripheral nerve | 10 | |
| Extracranial | Adipocytes | 10 | |
| Extracranial | Adrenal gland | Glandular cells | 10 |
| Extracranial | Bone marrow | Hematopoietic cells | 5 |
| Extracranial | Breast | 0 | |
| Extracranial | Bronchus | Epithelial cells | 0 |
| Neural tissue | Cerebral cortex | Endothelial cells | 0 |
| Extracranial | Intestine | 0 | |
| Extracranial | Esophagus | Squamous epithelial cells | 0 |
| Extracranial | Heart muscle | Myocytes | 0 |
| Extracranial | Kidney | 0 | |
| Extracranial | Liver | 0 | |
| Extracranial | Lung | 0 | |
| Extracranial | Lymph node | 0 | |
| Extracranial | Ovary | Follicle cells | 0 |
| Extracranial | Pancreas | 0 | |
| Extracranial | Parathyroid gland | Glandular cells | 0 |
| Extracranial | Salivary gland | Glandular cells | 0 |
| Extracranial | Seminal vesicle | Glandular cells | 0 |
| Extracranial | Skeletal muscle | Myocytes | 0 |
| Extracranial | Small intestine | Glandular cells | 0 |
| Extracranial | Spleen | 0 | |
| Extracranial | Testis | 0 | |
| Extracranial | Thyroid gland | Glandular cells | 0 |
| Extracranial | Tonsil | Germinal center cells | 0 |
| Extracranial | Vagina | Squamous epithelial cells | 0 |
Note: The color-coded column refers to data taken from www.proteinatlas.org.
Abbreviation: CNS, central nervous system.