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. 2018 Nov 8;13:7251–7273. doi: 10.2147/IJN.S173198

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© 2018 Huang et al. This work is published and licensed by Dove Medical Press Limited

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Schematic diagram of the study protocol.

Notes: (A) Synthesis of GEH NPs with EGCG loading for DES treatment in a rabbit model. (B) Inflamed cornea with higher inflammatory cytokine production observed in DES rabbit with low tear production. (C) Effective decrease of cornea inflammation and repair confirmed by GEH taken up by epithelium and use of EGCG inhibitor.

Abbreviations: DES, dry-eye syndrome; EGCG, epigallocatechin gallate; GEH, gelatin–EGCG with hyaluronic acid coating; GPs, gelatin NPs.