Table 2.
Receiver Operating Characteristic Curve Analysis for Discriminating Liver Cirrhosis
| AUROC | Cutoff | Sensitivity, % (No.) | Specificity, % (No.) | PPV, % (No.) | NPV, % (No.) | Accuracy, % (No.) | |
|---|---|---|---|---|---|---|---|
| log2 (let-7a-5p in serum) | 0.892 | –6.573 | 92 (23/25) | 80 (47/59) | 65 (22/34) | 94 (47/50) | 83 (70/84) |
| log10 (let-7a-5p in EVs) | 0.681 | –2.948 | 72 (18/25) | 61 (36/59) | 44 (18/41) | 84 (36/43) | 64 (54/84) |
| APRI | 0.788 | 0.859 | 80 (20/25) | 70 (41/59) | 51 (19/37) | 87 (41/47) | 73 (61/84) |
| FIB-4 | 0.783 | 2.745 | 84 (21/25) | 66 (39/59) | 50 (20/40) | 89 (39/44) | 71 (60/84) |
| M2BPGi, COI | 0.800 | 2.660 | 70 (16/23) | 83 (49/59) | 62 (16/26) | 88 (49/56) | 79 (65/82) |
| Liver stiffness, kPa | 0.909 | 9.9 | 96 (22/23) | 76 (45/59) | 61 (22/36) | 98 (45/46) | 82 (67/82) |
M2BPGi levels were not measured in 2 cases because of insufficiant sample volume. Transient elastgraphy for measuring liver stiffness was not performed in 2 cases.
Abbreviations: APRI, AST-to-platelet ratio index; AST, aspartate aminotransferase; AUROC, area under the receiver operating characteristic curve; COI, cutoff index; EVs, extracellular vesicles; FIB-4, fibrosis-4; M2BPGi, Mac-2 binding protein glycan isomer; NPV, negative predictive value; PPV, positive predictive value.