Table 2.

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) schedule

	Study period
	Enrolment	Allocation	Postallocation
Time point	-t1	0 Baseline	t1 3 months	t2 6 months	t3 12 months
Enrolment
Eligibility screen	X
Individual informed consent	X
Allocation		X
Interventions
(Standard treatment)		X	X
(Experimental treatment)		X	X
Assessments
Demographics		X	X	X	X
Physical functioning*		X	X	X	X
Knee pain†		X	X	X	X
HRQoL‡		X	X	X	X
Self-reported function§		X	X	X	X
Physical activity¶		X	X	X	X
PASS			X	X	X
Absenteeism**					X
Presenteeism††		X	X	X	X
Healthcare costs‡‡					X

*30 s chair stand test.

†Numeric rating scale (NRS) 0–10.

‡HRQoL, health-related quality of life measured using the EQ-5D-5L.

§KOOS-PS (Knee injury and Osteoarthritis Outcome Score–Physical Function Shortform).

¶The Swedish Board of Health and Welfare indicator questions.

**Productivity loss measured using data from the Social Insurance Agency’s Register.

††Productivity loss while working, measured using the Work Productivity and Activity Impairment Questionnaire (WPAI).

‡‡Estimated using data from the Swedish patient register, medication register and data from each participant’s primary care provider.

PASS, patient acceptable symptom state.