Table 4.

Analysis of risk factors for AD among patients with normal tension glaucoma

	Univariate analysis		Multivariate analysis
Predictive variables	Unadjusted HR	P values	Adjusted HR	P values
	(95% CI)		(95% CI)
Age
<55	Reference		Reference
55–65	5.14 (3.48 to 7.59)	<0.0001	4.74 (3.20 to 7.02)	<0.0001
65–75	14.65 (10.20 to 21.04)	<0.0001	12.83 (8.85 to 18.60)	<0.0001
≥75	34.06 (23.83 to 48.68)	<0.0001	29.01 (20.04 to 42.00)	<0.0001
Gender (male vs female)	0.93 (0.83 to 1.06)	0.28	0.81 (0.71 to 0.92)	0.0009
Comorbidities
Diabetes	1.36 (1.20 to 1.54)	<0.0001	1.01 (0.88 to 1.15)	0.91
Hypertension	2.99 (2.54 to 3.52)	<0.0001	1.11 (0.93 to 1.32)	0.27
Hyperlipidaemia	1.21 (1.07 to 1.37)	0.002	1.08 (0.95 to 1.23)	0.23
Coronary artery disease	2.21 (1.95 to 2.50)	<0.0001	1.14 (0.99 to 1.30)	0.06
Stroke	2.55 (2.21 to 2.94)	<0.0001	1.38 (1.19 to 1.60)	<0.0001
Types of glaucoma eye drops
α-agonist (yes vs no)	1.42 (1.20 to 1.69)	<0.0001	0.93 (0.82 to 1.06)	0.25
Carbonic anhydrase inhibitors (yes vs no)	0.80 (0.61 to 1.04)	0.09	0.89 (0.74 to 1.06)	0.19
β-blocker (yes vs no)	1.19 (0.83 to 1.69)	0.34	0.85 (0.70 to 1.04)	0.12
Parasympathomimetics (pilocarpine)	1.26 (0.52 to 3.02)	0.61	0.96 (0.68 to 1.36)	0.83
Prostaglandin analogues (yes vs no)	1.03 (0.88 to 1.21)	0.72	1.07 (0.93 to 1.23)	0.37

In the multivariate analysis, all the other variables listed in the table were included for adjustment.