Table 2.
Haematological profile of study population overall and by CKD (MDRD and CKD-EPI) status
| Variables | Total (n=1564) | MDRD | CKD-EPI | ||||
| Without CKD (n=1470) |
CKD (n=94) |
P values | Without CKD (n=1517) |
CKD (n=47) |
P values | ||
| RBC (x1012/L) | 4.7 (4.3–5.0) | 4.7 (4.4–5.0) | 4.3 (3.9–4.7) | <0.0001 | 4.7 (4.4–5.0) | 4.2 (3.8–4.7) | <0.0001 |
| WBC (x109/L) | 7.5 (6.2–9.1) | 7.4 (6.2–9.1) | 7.7 (6.5–9.2) | 0.5704 | 7.4 (6.2–9.1) | 7.9 (6.3–9.3) | 0.5458 |
| N/L (ratio) | 2.0 (1.5–2.6) | 1.9 (1.5–2.5) | 2.5 (1.7–3.5) | <0.0001 | 1.9 (1.5–2.5) | 2.7 (2.0–3.7) | <0.0001 |
| Lymphocyte count (x109/L) | 2.2 (1.8–2.80) | 2.2 (1.8–2.8) | 1.9 (1.4–2.5) | 0.0001 | 2.2 (1.8–2.8) | 1.8 (1.4–2.4) | <0.0001 |
| Monocyte count (x109/L) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.4 (0.4–0.6) | 0.1389 | 0.5 (0.4–0.6) | 0.4 (0.4–0.6) | 0.9446 |
| Neutrophil count (x109/L) | 4.5 (3.4–5.7) | 4.5 (3.3–5.6) | 5.0 (3.7–5.9) | 0.0255 | 4.5 (3.4–5.6) | 5.1 (4.3–6.1) | 0.0297 |
| Basophil count (x109/L) | 0.1 (0.1–0.2) | 0.0 (0.0–0.0) | 0.0 (0.0–0.1) | 0.283 | 0.0 (0.0–0.0) | 0.0 (0.0–0.1) | 0.1366 |
| Eosinophil count (x109/L) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.1579 | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.1223 |
| Platelet count (x109/L) | 271 (227–322) | 271 (228–322) | 277 (214–324) | 0.9417 | 271 (228–322) | 266 (197–313) | 0.2211 |
| Haematocrit (volume %) | 41 (39–44) | 41 (39–44) | 38 (35–41) | <0.0001 | 41 (39–44) | 37 (34–41) | <0.0001 |
| MCV (fl/cell) | 89 (85–93) | 89 (85–93) | 89 (86–92) | 0.8150 | 89 (85–93) | 89 (86–91) | 0.4748 |
| MCH (pg/cell) | 29 (28–31) | 29 (28–31) | 29 (28–30) | 0.1399 | 29 (28–31) | 29 (28–30) | 0.057 |
| MCHC (g/dL) | 33 (32–33) | 33 (32–33) | 33 (32–33) | 0.1471 | 33 (32–33) | 32 (32–33) | 0.1156 |
| RDW (%) | 14.2 (13.5–15.0) | 14.1 (13.4–15.0) | 14.5 (13.7–15.6) | 0.0601 | 14.1 (13.4–15.0) | 14.3 (13.8–15.5) | 0.0673 |
| Hb (g/dL) | 13.5 (12.6–14.4) | 13.5 (12.7–14.5) | 12.2 (11.2–13.3) | <0.0001 | 13.5 (12.6–14.4) | 11.9 (11.1–13.2) | <0.0001 |
| Anaemia, n (%) | 289 (18.48) | 249 (16.9) | 40 (45.5) | <0.0001 | 263 (17.3) | 26 (57.8) | <0.0001 |
| Microcytic | 83 (28.7) | 83 (33.3) | 0 (0.0) | – | 83 (31.6) | 0 (0.0) | – |
| Normocytic | 180 (62.3) | 141 (56.6) | 39 (97.5) | – | 155 (58.9) | 25 (96.2) | – |
| Macrocytic | 26 (9.0) | 25 (10.0) | 1 (2.5) | – | 25 (9.5) | 1 (3.8) | – |
Data are presented as median (25th-75th percentiles) and percentages.
CKD, chronic kidney disease; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; Hb, haemoglobin; MCH, mean corpuscular Hb; MCHC, MCH concentration; MCV, mean corpuscular volume; MDRD, Modification of Diet in Renal Disease; N/L ratio, lymphocyte to neutrophil ratio; RBC, red blood cells; RDW, red cell distribution width; WBC, white blood cells.