Table 3.
Linear regression coefficients, adjusted for age, gender (model 1) and eGFR (MDRD and CKD-EPI derived) (models 2) for the prediction of haematological-derived measures
| Model 1 | Model 2.1 | Model 2.2 | |||||||||||||
| Haematological-derived measures | Age | Gender | R2 | eGFR (MDRD) | R2 | eGFR (CKD-EPI) | R2 | ||||||||
| β | 95% CI | P values | β | 95% CI | P values | β | 95% CI | P values | β | 95% CI | P values | ||||
| RBC (x1012/L) | −2.8 | −4.5 to −1.2 | 0.001 | 327.4 | 269.6 to 385.3 | <0.0001 | 0.08 | 0.3 | −0.7 to 1.3 | 0.541 | 0.08 | 3.2 | 1.5 to 5.0 | <0.0001 | 0.09 |
| Haematocrit (%) | −0.2 | −0.3 to −0.0 | 0.018 | 40.2 | 35.3 to 45.1 | <0.0001 | 0.15 | 0.0 | −0.1 to 0.1 | 0.709 | 0.15 | 0.3 | 0.1 to 0.4 | <0.0001 | 0.16 |
| Hb (g/L) | −0.1 | −0.1 to −0.0 | 0.002 | 14.2 | 12.5 to 15.9 | <0.0001 | 0.16 | 0.0 | −0.0 to 0.0 | 0.907 | 0.16 | 0.1 | 0.0 to 0.1 | <0.0001 | 0.16 |
| WBC (x109/L) | −15.1 | −22.3 to −7.8 | <0.0001 | −431.9 | −690.8 to −173.0 | 0.001 | 0.01 | −0.5 | −4.8 to 3.9 | 0.834 | 0.01 | −1.7 | −9.7 to 6.3 | 0.678 | 0.01 |
| N/L (%) | −0.1 | −3.8 to 3.5 | 0.941 | 136.2 | 5.6 to 266.7 | 0.041 | 0.00 | −0.1 | −0.4 to 0.1 | 0.214 | 0.00 | −6.3 | −10.3 to −2.3 | 0.002 | 0.01 |
| Lymphocyte count (x106/L) | −2.9 | −5.2 to −0.5 | 0.017 | −257.10 | −341.0 to −173.2 | <0.0001 | 0.02 | 0.7 | −0.8 to 2.1 | 0.364 | 0.02 | 3.0 | 0.4 to 5.6 | 0.022 | 0.03 |
| Monocyte count (x106/L) | −0.8 | −1.4 to −0.2 | 0.005 | 91.6 | 71.2 to 112.0 | <0.0001 | 0.05 | 0.3 | −0.1 to 0.6 | 0.114 | 0.05 | 0.5 | −0.1 to 1.1 | 0.122 | 0.05 |
| Neutrophil count (x106/L) | −10.9 | −16.8 to −5.1 | <0.0001 | −291.8 | −500 to −82.8 | 0.006 | 0.01 | −1.1 | −4.6 to 2.4 | 0.542 | 0.01 | −4.7 | −11.1 to 1.7 | 0.150 | 0.01 |
| Basophil count (x106/L) | 1.6 | −8.4 to 11.5 | 0.759 | −187.9 | −541.9 to 166.1 | 0.298 | 0.00 | 0.7 | −5.3 to 6.6 | 0.822 | 0.00 | −8.3 | −19.2 to 2.6 | 0.136 | 0.00 |
| Eosinophil count (x106/L) | −0.5 | −1.1 to 0.0 | 0.067 | 15.9 | −4.9 to 36.7 | 0.135 | 0.00 | −0.4 | −0.7 to 0.0 | 0.071 | 0.00 | −0.6 | −1.2 to 0.1 | 0.074 | 0.00 |
| Platelet count (x109/L) | −0.4 | −0.6 to −0.1 | 0.003 | −33.0 | −42.0 to −24.0 | <0.0001 | 0.03 | 0.1 | −0.0 to 0.3 | 0.088 | 0.04 | 0.1 | −0.0 to 0.3 | 0.088 | 0.04 |
| MCV (fL/100 cell) | 1.4 | −1.0 to 3.7 | 0.255 | 232.2 | 148.1 to 316.2 | <0.0001 | 0.02 | −0.2 | −1.6 to 1.2 | 0.761 | 0.02 | 0.1 | −2.5 to 2.7 | 0.946 | 0.02 |
| MCH (pg/100 cell) | −0.2 | −1.1 to 0.7 | 0.698 | 95.3 | 63.3 to 127.4 | <0.0001 | 0.02 | −0.1 | −0.7 to 0.4 | 0.646 | 0.02 | 0.1 | −0.9 to 1.1 | 0.881 | 0.02 |
| MCHC (g/L) | −0.1 | −0.01 to −0.0 | <0.0001 | 2.3 | 0.9 to 3.8 | 0.002 | 0.02 | −0.0 | −0.0 to 0.0 | 0.227 | 0.02 | −0.0 | −0.1 to 0.0 | 0.664 | 0.01 |
| RDW (%) | 0.1 | 0.0 to 0.1 | 0.004 | −1.9 | −3.7 to −0.0 | 0.05 | 0.01 | 0.1 | 0.0 to 0.1 | <0.0001 | 0.02 | 0.1 | 0.0 to 0.1 | 0.025 | 0.01 |
Data presented as β-coefficient, 95% confidence interval CI and adjusted-R2.
Analyses are adjusted for age and gender.
Model 1 = age + gender; Model 2.1 = age + gender + eGFR (MDRD); Model 2.2 = age + gender + eGFR (CKD-EPI).
CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; Hb, haemoglobin; MCH, mean corpuscular Hb; MCHC, MCH concentration; MCV, mean corpuscular volume; MDRD, Modification of Diet in Renal Disease; N/L ratio, lymphocyte to neutrophil ratio; RBC, red blood cells; RDW, red cell distribution width; WBC, white blood cells.