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. 2018 Nov 12;13(11):e0207152. doi: 10.1371/journal.pone.0207152

Fig 3. Treatment with Lestaurtinib resulted in an antiproliferative effect on JAK2 knockout cell lines.

Fig 3

(A) Western blot showing loss of JAK2 expression following JAK2 knockout in CAL62 and KMH2 cell lines and compared to a non-targeting control. (B) Cellular proliferation of JAK2 knockout cell lines (CAL62 and KMH2) normalized to the non-targeting control and measured at 72 h. (C) Dose-response curves of CAL62 and KMH2 JAK2 knockout cells following 72 h of treatment with Lestaurtinib over a 6-point dose range (3 replicates per line). * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001, **** represents p < 0.0001, ns = not significant, Student’s unpaired, two-tail t-test.