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. 2018 Oct 26;7:e37344. doi: 10.7554/eLife.37344

Figure 5. Transcription factor binding enrichment in developmental and ageing promoter clusters.

Figure 5.

Transcription factor (TF) binding enrichments in developmental (A) or ageing (B) promoter clusters from Figure 4. TF-binding data are from modENCODE/modERN (Araya et al., 2014; Kudron et al., 2018); peaks in HOT regions were excluded (see Materials and methods). Only TFs enriched more than twofold in at least one cluster are shown, and only enrichments with a p<0.01 (Fisher’s exact test) are shown. Plots show TF binding enrichment odds ratio (left), expression of the TF in each tissue relative to its expression across all tissues (log2(TF tissue TPM/mean of the TF’s TPMs across all tissues), middle), and the decile of expression of the TF in each tissue (right; TPMs < 1 are not taken into account when calculating TPMs deciles). Expression data are from Cao et al. (2017). Legends for Figure Supplements.

Figure 5—source data 1. TF datasets used for analyses.
● factor transcription factor name. ● dataset_name modENCODE/modERN DCC dataset name(s), separated by commas if multiple datasets from the same transcription factor were used. ● dataset_id modENCODE/modERN DCC dataset ID(s), comma-separated as above.
elife-37344-fig5-data1.txt (7.1KB, txt)
DOI: 10.7554/eLife.37344.023