Table 1.

Features of final games.

Feature	Description	Function
Privacy	Making games about players fighting HIV conveys a risk of unintentionally revealing a patient’s HIV status when they would prefer privacy. To prevent this risk, we changed plans for a Body Voyage game fighting viruses and made 3 games designed to protect patient privacy and minimize the risk that using the intervention would disclose their status.	Increases app engagement by meeting the privacy needs of adolescent and young adult HIV patients.
Motivation	By making a direct connection between daily adherence and the kind of daily, in-game power-ups that players usually have to pay for with microtransactions, we attempted to motivate patients to take their medication on time. Opportunities to earn greater in-game power and access increases motivation for both engagement with the games and adherence with antiretroviral treatment (ART).	Direct motivation to increase adherence.
Motivation	The game incentivizes cooperation by letting the player build up available healing tiles and defensive tiles by not using them on less-injured heroes but instead saving them up for bigger healing effects on heroes who are more injured. In this way, the game puts the player in a caregiver role.	Having player in caregiver role motivates patients in their current self-care role to adhere to their ART.
Information	The system knows when patients do not open their pillboxes on time and sends out a feedback reminder when this happens in the form of a text message (which does not disclose anything about HIV).	Providing this timely information about adherence affirms adherence behavior and serves as a cue to action in a way that does not breach privacy.