Table 5.
Summary of repeated measures analyses of outcomes: participant-rated measures (intention-to-treat population).
| Participant-rated measures | Blended CBTa, mean (SD) | Waiting list, mean (SD) | Difference in mean change scoresb,c (95% CI) | P value | |
| 17-item GRID-Hamilton Depression Rating Scale score | |||||
|
|
0 week (baseline) | 18.3 (3.6) | 18.5 (3.6) | N/Ad | N/A |
|
|
6 weeks | 14.0 (5.7) | 16.1 (4.7) | 1.90 (−1.46 to 5.26) | .26 |
|
|
12 weeks | 9.4 (5.1) | 15.5 (6.3) | 5.95 (2.37 to 9.53) | .002 |
|
|
24 weeks (3-month follow-up) only CBT | 7.2 (5.7) | N/A | N/A | N/A |
| Beck Depression Inventory-Second Edition score | |||||
|
|
0 week (baseline) | 28.0 (8.6) | 24.4 (7.6) | N/A | N/A |
|
|
6 weeks | 23.4 (11.2) | 20.1 (8.2) | 0.35 (−4.63 to 5.33) | .89 |
|
|
12 weeks | 18.5 (12.3) | 20.8 (9.1) | 5.85 (−0.27 to 11.97) | .06 |
|
|
24 weeks (3-month follow-up) only CBT | 14.7 (12.5) | N/A | N/A | N/A |
| Quick Inventory of Depressive Symptomatology Self-Report score | |||||
|
|
0 week (baseline) | 14.8 (4.0) | 13.5 (3.9) | N/A | N/A |
|
|
6 weeks | 7.9 (3.7) | 8.7 (3.8) | 2.20 (−0.66 to 5.06) | .13 |
|
|
12 weeks | 8.0 (4.7) | 10.2 (4.2) | 3.55 (0.53 to 6.57) | .02 |
|
|
24 weeks (3-month follow-up) only CBT | 6.8 (5.5) | N/A | N/A | N/A |
| Dysfunctional attitude scale score | |||||
|
|
0 week (baseline) | 97.1 (19.0) | 87.6 (17.1) | N/A | N/A |
|
|
6 weeks | 97.4 (19.2) | 86.1 (17.8) | −1.80 (−9.23 to 5.63) | .63 |
|
|
12 weeks | 92.4 (23.6) | 84.9 (18.5) | 2.05 (−6.82 to 10.92) | .64 |
|
|
24 weeks (3-month follow-up) only CBT | 83.4 (21.8) | N/A | N/A | N/A |
| European Quality of Life Questionnaire-5 Dimensions score | |||||
|
|
0 week (baseline) | 0.7 (0.1) | 0.7 (0.1) | N/A | N/A |
|
|
6 weeks | 0.8 (0.1) | 0.8 (0.1) | −0.04 (−0.12 to 0.04) | .29 |
|
|
12 weeks | 0.8 (0.1) | 0.8 (0.1) | −0.07 (−0.16 to 0.01) | .08 |
|
|
24 weeks (3-month follow-up) only CBT | 0.8 (0.1) | N/A | N/A | N/A |
| 36-item Short-Form Health Survey (SF-36) mental component summary score | |||||
|
|
0 week (baseline) | 37.7 (10.6) | 37.8 (7.7) | N/A | N/A |
|
|
6 weeks | 39.5 (9.7) | 41.6 (8.3) | 1.96 (−3.45 to 7.37) | .47 |
|
|
12 weeks | 43.9 (10.2) | 41.3 (7.9) | −2.70 (−8.91 to 3.50) | .38 |
|
|
24 weeks (3-month follow-up) only CBT | 44.6 (11.1) | N/A | N/A | N/A |
| SF-36 physical component summary score | |||||
|
|
0 week (baseline) | 52.8 (11.2) | 51.7 (10.8) | N/A | N/A |
|
|
6 weeks | 50.8 (11.0) | 53.5 (7.4) | 3.87 (−1.90 to 9.64) | .18 |
|
|
12 weeks | 49.4 (13.5) | 53.4 (10.6) | 5.04 (−2.81 to 12.89) | .20 |
|
|
24 weeks (3-month follow-up) only CBT | 52.8 (9.6) | N/A | N/A | N/A |
aCBT: cognitive behavioral therapy.
bThe difference in the mean change in scores is the intergroup difference in the least squares mean treatment change score from the baseline to the data point, from the mixed-effects model for repeated measures analysis.
cThe intergroup difference is the CBT group value minus the waiting list group value.
dN/A: not applicable.