Table 2. Age- and Multivariable-Adjusted Relative Risks for Clinical Vertebral Fracture According to PPI and H2-Receptor Antagonist Use*.
| PPI Use | ||
|---|---|---|
|
| ||
| No | Yes | |
| Cases of Vertebral Fracture (n) | 426 | 121 |
| Person-years (n) | 523,600 | 83,248 |
| Age-adjusted Relative Risk (95% CI) | 1.00 (reference) | 1.44 (1.17, 1.77) |
| Multivariate Relative Risk (95% CI) † (Model without osteoporosis) | 1.00 (reference) | 1.36 (1.11, 1.68) |
| Multivariate Relative Risk (95% CI) †† (Model with osteoporosis) | 1.00 (reference) | 1.29 (1.04, 1.59) |
|
|
||
| H2-Receptor Antagonist Use | ||
|
|
||
| No | Yes | |
| Cases of Vertebral Fracture (n) | 503 | 44 |
| Person-years (n) | 569,267 | 37,580 |
| Age-adjusted Relative Risk (95% CI) | 1.00 (reference) | 1.34 (0.98, 1.82) |
| Multivariate Relative Risk (95% CI) † (Model without osteoporosis) | 1.00 (reference) | 1.26 (0.92, 1.72) |
| Multivariate Relative Risk (95% CI) †† (Model with osteoporosis) | 1.00 (reference) | 1.22 (0.90, 1.67) |
PPI and H2-Receptor Antagonist use were updated throughout the analysis period (2002-2014). Relative risks are for the risk of vertebral fracture compared with the group that did not use PPIs or H2-Receptor Antagonists.
The multivariate model includes body mass index, race, physical activity, history of falls, smoking status, alcohol intake, supplemental calcium intake, quintiles of diet calcium intake, total vitamin D intake, vitamin A intake, total protein intake, history of diabetes, postmenopausal hormone use, and recent physical exam.
The multivariate model includes body mass index, race, physical activity, history of falls, smoking status, alcohol intake, supplemental calcium intake, quintiles of diet calcium intake, total vitamin D intake, vitamin A intake, total protein intake, history of diabetes, self-reported osteoporosis, postmenopausal hormone use, and recent physical exam.