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. 2018 Nov 6;9:1219. doi: 10.3389/fphar.2018.01219

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Copyright © 2018 Alshamsan, Kazi, Badran and Alanazi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GRAPHICAL ABSTRACT — Improving fenofibrate solubility using lipid-based self-nanoemulsifying systems. Drug solubilization required for drug absorption for an anticipated systemic effect of an orally administered drug. Self-nanoemulsifying drug delivery systems (SNEDDS) have generated significant interest across the pharmaceutical industry as potentially innovative systems to maintain poorly water soluble drug in solubilized form for rapid absorption. Schematic Diagram: Intestinal drug transport mechanism after ingestion of lipid-based SNEDDS dosage form.