Table 5.
No. | Formulation | Fasted |
Fed |
||||
---|---|---|---|---|---|---|---|
% Drug in AP | % Drug in PP | %Tot. Rec. | % Drug in AP | % Drug in PP | %Tot. Rec. | ||
F2a | C70:CMCM(7:3)/TO106V (1/1) | 9.22 ± 0.67 | 79.23 ± 1.23 | 88.45 | 8.99 ± 1.11 | 78.99 ± 0.77 | 87.98 |
F2b | K70:I742(7:3)/To-106V(1/1) | 11.23 ± 3.23 | 84.79 ± 0.87 | 96.02 | 10.09 ± 0.21 | 83.36 ± 1.07 | 93.45 |
F3a | C70:CMCM(7:3)/ HCO-30 (1/1) | 08.24 ± 0.00 | 78.72 ± 0.20 | 86.96 | 07.20 ± 0.61 | 85.44 ± 0.02 | 92.64 |
F3b | K70:I742(7:3)/HCO-30 (1/1) | 10.18 ± 0.00 | 83.41 ± 0.80 | 93.59 | 4.84 ± 0.00 | 88.68 ± 1.11 | 93.52 |
F4a | CMCM/HCO-30 (1/1) | 7.64 ± 2.11 | 84.81 ± 0.44 | 92.45 | 7.43 ± 1.32 | 84.23 ± 3.11 | 91.66 |
F4b | I742/ HCO-30 (1/1) | 9.79 ± 0.03 | 86.75 ± 0.00 | 96.54 | 8.75 ± 0.50 | 85.29 ± 0.93 | 92.04 |
Concentration of fenofibrate (mg) in mixed BS micelles before and after digestion under fed conditions. The data represent the original mass of fenofibrate which was recovered from the aqueous and pellet phases after digestion.