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The suggested mechanism of hepatic metabolism of ICG. Hepatic uptake of ICG is facilitated by OATP1B3 and NTCP. During the intracellular transportation of ICG, it binds to the GST isozyme, forming phospholipid vesicles and bile salt/lipid hybrid micelles. Biliary excretion is facilitated by MDR3 and MRP2. ICG, indocyanine green; NTCP, Na+-taurocholate co-transporting polypeptide; GST, glutathione S-transferase.
