Table 1.
The effects of acute alcohol administration on amygdala reactivity in human imaging studies.
| Study |
N
(% Male) |
EPI Voxel Size (mm3) | Normalizationa | Design | Task | Amygdala Results |
|---|---|---|---|---|---|---|
| Present study | 49 (53%) | 8.0 | FSL (BBR) and ANTS (diffeomorphic) | Single-blind, placebo-controlled, randomized groups | Fearful/Neutral Faces vs. Places (blocked) | See the main report |
| Gilman 2008 | 12 (42%) | 70.3 | “AFNI” (affine?) | Double-blind, placebo-controlled, randomized cross-over | Fearful vs. Neutral Faces (event-related) |
Voxelwise
a. Expression × Treatment, NS b. Expression during Placebo: Fearful > Neutral, p < 0.05, corrected c. Expression during Alcohol: Fearful vs. Neutral, NS ROI a. Expression × Treatment, p = 0.08 b. Expression during Placebo: Fearful > Neutral, p < 0.05 c. Expression during Alcohol: Fearful vs. Neutral, NS |
| Gilman 2012b | 14 (100%) | 70.3 | “AFNI” (affine?) | Double-blind, placebo-controlled, randomized cross-over | Fearful vs. Neutral Faces (event-related) |
Voxelwise
a. Expression × Treatment, NR b. Expression during Placebo: Fearful > Neutral, p < 0.01, corrected c. Expression during Alcohol: Fearful vs. Neutral, NS ROI a. Expression × Treatment, p = 0.02 b. Treatment for Neutral: NR c. Treatment for Fearful: Alcohol < Placebo, p = 0.02 |
| Padula 2011c | 12 (58%) | 58.8 | “AFNI” (affine?) | Single-blind, placebo-controlled, randomized cross-over | Angry/Fearful/Happy Faces vs. Shapes (blocked) |
Voxelwise
a. Stimulus × Treatment, NS b. Stimulus during Placebo: Faces > Shapes, p < 0.05, corrected c. Stimulus during Alcohol: Faces vs. Shapes, NS |
| Sripada 2011 | 12 (83%) | 70.3 | SPM12 (EPI template) | Double-blind, placebo-controlled, randomized cross-over | Fearful/Angry vs. Happy Faces (blocked) |
Voxelwise
a. Expression × Treatment, NS b. Expression during Placebo: Fearful/Angry > Happy, p < 0.005, uncorrected c. Expression during Alcohol: Fearful/Angry vs. Happy, NS d. Treatment during Fearful/Angry: Alcohol < Placebo, p < 0.005, uncorrected d. Treatment during Happy: NR ROI a. Expression × Treatment, NR b. Expression during Placebo: Fearful/Angry > Happy, p < 0.05 c. Expression during Alcohol: Alcohol < Placebo, NS |
aOlder normalization techniques (e.g., affine, EPI-to-EPI) can introduce substantial spatial smoothing and registration error, which is a concern for work focused on small subcortical structures, such as the EAc. bSocial drinker (‘control’) group. cROI analyses were not reported. Abbreviations—BBR, boundary-based registration of the T1- and T2-weighted images; NR, not reported; NS, not significant.