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. 2018 Nov 12;8:16668. doi: 10.1038/s41598-018-35072-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change in Shannon indices for c-MYC copy number variation (CNV) after neoadjuvant chemotherapy according to chemo-responsiveness. (A) In the whole group, Shannon indices for c-MYC CNV after neoadjuvant chemotherapy (NAC) are significantly decreased compared to those before NAC. (B) In the chemo-sensitive group composed of Miller-Payne regression grade 3 and 4, Shannon indices are significantly decreased in post-NAC samples compared to pre-NAC samples. (C) In the chemo-resistant group including Miller-Payne regression grade 1 and 2, there is no difference between Shannon indices before and after NAC. The box shows the first to third quartiles and the horizontal line inside the box represents the median. The whiskers extend to minimum and maximum values within 1.5 times the interquartile range from the first and third quartiles, and the outliers are represented by small circles.