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. 2018 Nov 12;8:16668. doi: 10.1038/s41598-018-35072-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier survival analyses based on c-MYC copy number variation (CNV) before and after neoadjuvant chemotherapy. In the pre-neoadjuvant chemotherapy (NAC) samples, c-MYC amplification (A) and copy number gain (B) were not associated with disease-free survival of the patients, while a high Shannon index for c-MYC CNV (C) shows a significant association with poor disease-free survival. Similarly, in the post-NAC samples, c-MYC amplification (D) and copy number gain (E) were not associated with disease-free survival, and a high Shannon index (F) shows a significant association with poor disease-free survival.