Table 2.

Clinical characteristics of the reactions based on data reported by patients.

		Blended n = 261	NERD n = 108	NIUA n = 511	p-value Blended vs NERD vs NIUA	p-value Blended vs NERD	p-value Blended vs NIUA	p-value NERD vs NIUA
Time interval drug-reaction, median (IQR) (min)		30 (20–90)	30 (15–120)	60 (30–120)	0.001	NS	0.0003	NS
Drugs involved n, (%)	ASA	105 (39.9)	34 (31.5)	194 (38)	NS	NS	NS	NS
	Indomethacin	3 (1.1)	—	7 (1.4)	NS	NS	NS	NS
	Diclofenac	59 (22.6)	20 (18.5)	106 (20.7)	NS	NS	NS	NS
	Ibuprofen	142 (54.4)	66 (61.1)	337 (65.7)	NS	NS	NS	NS
	Naproxen	18 (6.9)	6 (5.5)	36 (34.8)	NS	NS	NS	NS
	Dexketoprofen	18 (6.9)	8 (7.4)	44 (8.5)	NS	NS	NS	NS
	Dipyrone	108 (41.4)	30 (27.8)	205 (40)	0.004	0.004	NS	0.03
	Piroxicam	9 (3.4)	3 (2.8)	16 (3.1)	NS	NS	NS	NS
	Paracetamol	52 (19.9)	15 (13.9)	141 (27.5)	0.003	NS	NS	0.002
	Meloxicam	2 (0.8)	1 (0.9)	2 (0.4)	NS	NS	NS	NS
	Lysine clonixinate	7 (2.7)	2 (1.8)	9 (1.8)	NS	NS	NS	NS
	Selective COX-2	3 (1.1)	—	6 (1.2)	NS	NS	NS	NS
Number of episodes, median (IQR)		3 (2–4)	3 (2–4)	3 (3–4)	NS	NS	NS	NS
Number of drugs involved, median (IQR)		3 (1.25–3)	2 (1–3)	2 (2–3)	NS	NS	NS	NS
Time interval between the last reactions and diagnosis, median (IQR)		7 (3–24)	7 (5.5–8.5)	5 (2–23)	NS	NS	NS	NS

IQR: interquartile range; NS: Non significant.