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. 2018 Nov 12;8:16699. doi: 10.1038/s41598-018-35139-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Both miR-33a-5p and miR-128-3p were down-regulated in lung cancer tissues and lung cancer cell lines. MiR-33a-5p (A) and miR-128-3p (B) showed a statistically down-regulated expression in each lung cancer tissues and the matched adjacent normal tissues (n = 65, P < 0.001). The relative expression of miR-33a-5p (C) and miR-128-3p (D) in 65 paired lung cancer tissues and matched adjacent normal tissues. Results were presented as the fold-change in tumor tissues compared to adjacent normal tissues. (E) Pearson correlation coefficient showed that the relative expressions of miR-33a-5p and miR-128-3p were significantly positively correlated in lung cancer tissues (P = 0.0008). Compared with normal lung epithelial cell (BEAS-2B), the relative expressions of miR-33a-5p (F) and miR-128-3p (G) were significantly lower in four lung cancer cell lines (NCI-H1299, A549, SPC-A-1, and LTEP-a-2, P < 0.05). *P < 0.05, **P < 0.01, ***P < 0.001.