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. 2018 Nov 12;8:16699. doi: 10.1038/s41598-018-35139-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-33a-5p and miR-128-3p could be used to distinguish early-stage lung cancer patients from healthy controls. MiR-33a-5p (A) and miR-128-3p (C) were down-regulated in early lung cancer patients (TNM stage I-II) compared to healthy controls (P < 0.001). The ROC analysis for detection of early lung cancer patients from health controls using miR-33a-5p (B), miR-128-3p (D), and miR-33a-5p + miR-128-3p (E). (F) The comparison of diagnostic values between miR-33a-5p, miR-128-3p and the combination. ***P < 0.001.