Fig. 2. TTC7A is a nuclear factor that associates to chromatin.

a TTC7A chromatin-binding sites are shown by using IGV genomic browser. Flag-tagged TTC7A ChIP-seq is presented as a pile-up of reads, and a representative enrichment on chromosome 19 is displayed. Bars depict significant enriched regions common in both IP1 and IP2 performed with two distinct antibodies. b ChIP-seq peaks annotation of TTC7A. c Gene type distribution of nearby genes for TTC7A peaks. TTC7A-enriched peaks are associated with the genes whose TSS is the closest and genes features category is provided. d Ingenuity pathways analysis (IPA) disease and function analysis. Genes that TSS localizes within 10 kb distance from the summit of TTC7A peaks (common IP1 and IP2 peaks) corresponded to functions such as cellular growth and maintenance, cell metabolism, survival, gene expression, and DNA damage