Table 1.
Significant correlation of ARID5BlowPHF2low expression with high-risk markers in B-ALL
| Characteristics | ARID5B low PHF2 low | non-ARID5B low PHF2 low | Univariate analyses (Chi-Square Tests) | Multivariate analyses (Multivariate Cox model) | |
|---|---|---|---|---|---|
| P value | P value | HR(95% CI) | |||
| IKZF1 deletion (IK6 expressing) (%) | 49.3 | 15.8 | 0.001 | 0.001 | 0.062 (0.013–0.298) |
| Blasts (%) median (range) bone marrow | 91.2 (59.0–100.0) | 82.4 (28.0–98.0) | 0.000 | 0.038 | 0.005 (0.000–0.742) |
| Extramedullary infiltration (%) spleen | 50.0 | 22.9 | 0.008 | 0.964 | 1.032 (0.264–4.029) |
| Stem cell marker CD34 + (%) | 88.2 | 55.6 | 0.000 | 0.135 | 0.370 (0.100–1.362) |
| Myeloid marker CD33 + (%) | 50.9 | 28.6 | 0.036 | 0.711 | 1.307 (0.317–5.381) |
| Time to CR after treatment is > 4 weeks (%) | 53.0 | 21.2 | 0.003 | 0.002 | 0.132 (0.036–0.478) |