Table 1.
Voltage dependence of steady-state activation, fast and slow inactivation for WT and mutant A204E hNav1.4 channels.
| Steady state activation | Fast inactivation | Slow inactivation | ||||
|---|---|---|---|---|---|---|
| V1/2 (mV) | k v | V1/2 (mV) | k v | V1/2 (mV) | k v | |
| WT | −32.0 ± 1.1 (36) | 3.9 ± 0.2 (36) | −69.7 ± 0.7 (36) | 4.0 ± 0.0 (36) | −69.5 ± 0.9 (11) | 5.0 ± 0.2 (11) |
| A204E | −35.0 ± 1.1 (28)* | 6.4 ± 0.2 (28)*** | −76.0 ± 0.7 (28)*** | 3.7 ± 0.1 (28)*** | −77.0 ± 0.8 (14)** | 5.1 ± 0.2 (14) |
V1/2, midpoint for activation or inactivation (mV); k, slope factor for activation or inactivation. The numbers of cells (n) are in brackets. Values are means ± sem. *P < 0.05, **P < 0.01, ***P < 0.001.