Table 3.

Comparison of biophysical parameters of A204E and R1451L mutant channels recorded at 4 mM K⁺_ext.

Mutation	Current density	Steady state activation		Fast inactivation			Window current$	Slow inactivation
		V1/2	kv	V1/2	kv	τ
A204E	50%	−3 mV	164%	−6.3 mV	92%	28%	7-fold increase	Faster entry, slower recovery
R1451L	46%	ns	136%	−19.6 mV	224%	30%	7-fold increase	Slower recovery

The parameters considered here are those reported to be statistically different between the mutant (A204E or R1451L) and the WT channels (this study for A204E or Poulain et al.¹¹ for R1451L). All data are expressed as percent of WT values (equal to 100%) except the midpoints for steady-state activation and fast inactivation (V_1/2). V_1/2, differences (mV) between the midpoints for activation or fast inactivation of the mutant channels (A204E or R1451L) and those of WT channels (WT); k, slope factor for voltage dependence of activation or inactivation; τ, time constants of entry into fast inactivation at −50 mV. ^$Probability to be in the window current. ns, not significant.