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. 2018 Nov 12;9:4748. doi: 10.1038/s41467-018-07200-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — HEV-1 replication in explants derived from the decidua and placenta generates infectious progeny particles. Freshly isolated stromal cells a, b, or the HepG2/C3A cell line c, d, were challenged with culture supernatants (SN) from either HEV-1 (red), or HEV-3 (cyan) infected decidual a, c, or placental b, d explants. Viral replication was then followed over a 2-week period by RT-qPCR. Data represent means values ± S.E.M. of six independent donors. * denotes a statistical comparison made between HEV-1 and HEV-3 infected cells. **P < 0.01; ***P < 0.001 by two-way ANOVA with Bonferroni post hoc test.