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. 2018 Nov 12;8:16673. doi: 10.1038/s41598-018-34898-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Near Infra-Red Fluorescence (NIRF) imaging of IR780 dye tagged Toco-Photoxil and FA-Toco-Photoxil after systemic delivery in HT1080 FR(−) xenograft and 4T1 FR(+) orthotopic tumor-bearing mice. (a) Representative NIRF images of HT1080 xenograft and 4T1 syngeneic tumor bearing mice at different time points after systemic delivery of IR780-Toco-Photoxil (top), IR780-FA-Toco-Photoxil (middle), and IR780 dye control (bottom). (b) Quantitative assessment of fluorescence signal in HT1080 tumors of mice injected with IR780-Toco-Photoxil, and IR780-FA-Toco-Photoxil. (c) Quantitative assessment of fluorescence signal in 4T1 tumors of mice injected with IR780-Toco-Photoxil, and IR780-FA-Toco-Photoxil.