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. 2018 Nov 12;8:16673. doi: 10.1038/s41598-018-34898-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Photothermal therapy after systemic delivery of Toco-Photoxil and percentage accumulation in tumor in comparison to other surface modified Toco-Photoxil. (a) Qualitative representation of TurboFP fluorescence images of mice bearing HT1080-fluc2-turboFP tumors during the course of photothermal treatment (arrow head indicates the treated tumor region). (b) Quantitative assessment of changes in light output of the TurboFP fluorescent protein (P < 0.01). (c) Representative follow up bioluminescence images of mice at day 10 (arrow head indicates the treated tumor region). (d) Fold change in bioluminescence light output between the vehicle control treated mice and mice treated with a combination of Toco-Photoxil and 750 nm laser. (e) Percentage tumor uptake of Toco-Photoxil, FA-Toco-Photoxil, IR780-Toco-Photoxil, and IR780-FA-Toco-Photoxil (**** indicates P < 0.0001). (f) FEG-TEM images of 4T1 tumor section showing accumulation of Toco-Photoxil.