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. 2018 Nov 6;9:1255. doi: 10.3389/fphar.2018.01255

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Copyright © 2018 Trung and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of stress ligands in tumor cells by resveratrol. Cancer cells exposed to resveratrol upregulate stress proteins, such as death receptor 5 (DR5) or ligands for the immune receptor NKG2D including MICA or ULBPs. The engagement of these proteins by immune cells expressing the corresponding receptor (NKG2D receptor) or ligand (TRAIL), result in cancer cell death.