Table 2.

Summarized data about clinicopathologic features of 19 cases of head and neck LCH from Brazil and Guatemala

N, Country	Age (years)	Gender	Unifocal site	Multifocal sites	Pain	GI	Tooth mobility	Eosinophils	Giant cells	Necrosis	Ki-67 index
1 Guatemala	1	M	–	Mand, anta; Max, post; Skull	No	Yes	Yes	< 5%	Yes	No	33%
2 Guatemala	2	M	LN, cervicala	–	No	No	No	< 5%	Yes	No	26%
3 Guatemala	2	M	Gingivaa	–	Yes	Yes	No	< 5%	No	No	19%
4 Guatemala	2	F	Max, posta	–	No	Yes	Yes	> 50%	No	Yes	40%
5 Guatemala	9	F	Mand, posta	–	No	No	Yes	< 5%	Yes	Yes	48%
6 Guatemala	NR	F	Max, posta	–	No	No	Yes	5–50%	No	No	32%
7 Brazilc	1 m	M	–	Scalpa; Skin; Liver, Spleen, Thymus	Yes	No	No	< 5%	No	No	37%
8 Brazil	1	F	–	Scalpa; Skin; Hard palate; LN, cervical; GIT	Yes	No	No	zero	No	No	5%
9 Brazil	1	F	LN, cervicala	–	No	No	No	5–50%	No	No	36%
10 Brazilc	4	M	–	LN, cervicala; Skull; Skin; Liver	Yes	No	No	5–50%	Yes	No	23%
11 Brazil	4	M	–	Mand anta; Skin	No	Yes	Yes	> 50%	No	No	25%
12 Brazil	9	F	Mand, anta	–	No	Yes	Yes	< 5%	No	No	6%
13 Brazil	10	M	Mand, posta	–	Yes	No	No	5–50%	No	No	33%
14 Brazil	12	F	Mand, posta	–	Yes	No	No	5–50%	No	No	23%
15 Brazil	18	F	–	Mand, posta; Max post; Skull	No	No	No	> 50%	No	Yes	48%
16 Brazil	23	M	–	Mand, anta; Bilateral Max, post	No	No	Yes	> 50%	No	Yes	5%
17 Brazilb	24	F	–	Mand, anta; upper gingiva, ant	No	Yes	No	< 5%	No	No	26%
18 Brazil	34	M	–	Mand, anta; Hard palate	Yes	No	No	5–50%	No	Yes	21%
19 Brazilb	51	F	Mand, posta	–	Yes	Yes	No	> 50%	No	No	29%
Total	11.5 (1 m—51)	F—10 cases M—9 cases	10 cases	9 cases	Yes—8 No—11	Yes—7 No—12	Yes—7 No—12	< 5%—7 cases 5–50%—6 cases > 50%—5 cases	Yes—4 No—15	Yes—5 No—14	0–20%—4 cases 21–40%—13 cases 41–50%—2 cases

LCH Langerhans cell histiocytosis, GI gingival involvement, NR not reported, M male, F female, Mand mandible, Max maxilla, ant anterior, post posterior, LN Lymph node, GIT gastrointestinal tract

^aSite of the biopsied lesion

^bPatient with recurrence

^cPatient died of the disease