Table 2.
Clinicopathologic features by cytokeratin 7 expression
| Characteristics | Oropharyngeal SCC, n: 204 (%) | Nonoropharyngeal SCC, n: 74 (%) | ||
|---|---|---|---|---|
| Cytokeratin 7 positive, n: 47 (%) | Cytokeratin 7 negative, n: 157 (%) | Cytokeratin 7 positive, n: 11 (%) | Cytokeratin 7 negative, n: 63 (%) | |
| Sex | ||||
| Male | 41 (89.3) | 136 (86.6) | 8 (72.7) | 50 (79.3) |
| Female | 6 (12.7) | 21 (13.4) | 3 (27.3) | 13 (20.7) |
| Race | ||||
| Caucasian | 44 (93.6) | 138 (87.9) | 9 (81.2) | 51 (80.9) |
| Non-Caucasian | 3 (6.4%) | 19 (12.1) | 2 (18.2) | 12 (19.0) |
| Mean and median age in years | 55.1, 54 | 56.2, 55 | 67.1, 64 | 69.9, 71 |
| Smoking status | ||||
| Smoker (current or former) | 32 (68.0) | 118 (75.1) | 1 (9.1) | 59 (93.6) |
| Non-smoker | 15 (32.0) | 39 (24.8) | 10 (90.9) | 4 (6.4) |
| HPV status | ||||
| HPV RNA ISH positive | 35 (74.4) | 108 (68.8) | 0 | 2 (3.1) |
| HPV RNA ISH negative | 12 (25.6) | 49 (31.2) | 11 (100) | 61 (96.9) |
| Morphology | ||||
| Keratinizing | 8 (17.0) | 39 (24.8) | 11 (100) | 63 (100) |
| Non-keratinizing with maturation | 8 (17.0) | 36 (22.9) | 0 | 0 |
| Non-keratinizing | 31 (66.0) | 82 (52.2) | 0 | 0 |
| AJCC stagea | ||||
| I | 2 (4.2) | 4 (2.5) | 1 (9.1) | 3 (4.7) |
| II | 2 (4.2) | 10 (6.3) | 0 | 9 (14.3) |
| III | 2 (4.2) | 29 (18.4) | 3 (27.3) | 10 (15.8) |
| IV | 40 (85.1) | 113 (71.9) | 7 (63.6) | 32 (50.8) |
SCC squamous cell carcinoma
aData on staging was not available on all cases