Table 2.
Histological and immunohistochemical features of sinonasal leiomyosarcomas (n = 9)
| No. | Histology | Grade | SMA | Desmin | h-caldesmon | HMB45 | S100 | EBER ISH | Rb1 | TP53 | MDM2 | CDK4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Conventional | G3 | +++ | +++ | +++ | − | − | − | Lost | − | − | − |
| 2 | Conventional low-grade | Initially G1; recurrence G2; Metastasis G3 | +++ | +++ | +++ | − | − | − | Lost | − | − | − |
| 3 | Conventional | G3 | + | +++ | +++ | − | − | − | Lost | − | − | − |
| 4 | clear cell, glycogen-rich | G3 | +++ | ++ | +++ | − | − | np | np | np | − | np |
| 5 | Conventional low-grade with dedifferentiation | G1 + G3 | +++ | − | − | − | − | − | Lost | − | − | − |
| 6 | Conventional | G3 | +++ | +++ | − | − | − | − | Intact | +++ | − | − |
| 7 | Conventional, focal myxoid | G2 | +++ | +++ | +++ | − | − | − | Lost | − | − | − |
| 8 | Conventional with clear cell and dedifferentiated (inflammatory MFH-like) | G1 + G3 | +++ | +++ | +/− | − | − | − | Lost | − | − | − |
| 9 | Conventional, focal epithelioid | G3 | +++ | − | ++ | − | − | − | Intact | − | − | − |
ISH in-situ hybridization, np not performed, SMA smooth muscle actin, EBER ISH Epstein Barr virus in-situ hybridization