Table 1.

Summary of the literature regarding mutant genes involved in PCs cases.

References	Sex	Age	PC type	Metastasis location	Mutation gene	Treatment	Follow-up
Greenman et al. (2)	Female	37 y	Growth hormone secreting	Left neck lymph node	NA	Surgery+ Medicine	NA
Nose-Alberti et al. (3)	Female	22 y	ACTH secreting	Live	c-erbB-2	Surgery	Died after 4 months
Roncaroli et al. (4)	Male Female	55 y 53 y	FSH secreting FSH secreting	Skull base, nasal sinuses, and larynx, Vertebral bodies and ribs	HER-2/neu	Surgery Surgery + chemotherapy (cyclophosphamide, vincristine, dacarbazine)	Died after 2 years Stable 19 years
Scheithauer et al. (5)	Male	19 y	Thyrotropin secreting	Foramen magnum and cervical 2–3 levels	MEN1	Surgery + chemotherapy (octreotide)	18 years
Wei et al. (6)	Female	50 y	Non-functioning	Multiple intracranial metastases	miR-20a, miR-106b, miR-17-5p	Surgery + radiation + chemotherapy (Temozolomide)	Died after 8 months
Casar-Borota et al. (7)	Male Female	35 y 39 y	ACTH secreting	NA	ATRX DAXX	NA	NA
Present case	Male	60 y	ACTH secreting	Lung	PTEN, ATRX, P53	Surgery + radiation + chemotherapy (Temozolomide)	3-months follow-up remaining

ACTH, adrenocorticotropichormone; ATRX, alpha thalassemia/mental retardation syndrome X-linked; DAXX, death-domain-associated protein; NA, none available; PTEN, phosphatase and tension homolog deleted on chromosome 10; y, years.