Table 1.

Substrates for ADAM 10 and 17 in the kidneys.

Substrates	ADAMs	Associated diseases
CADM1	10	Diabetic nephropathy, arterionephroscrelosis
E-cadherin	10	Autosomal dominant polycystic kidney disease
CXCL16	10	Lupus nephritis, acute tubular necrosis
TNF-α	17	Lupus nephritis, diabetic nephropathy, acute kidney injury
EGFR ligands	17	Renal fibrosis, polycystic kidney disease
ACE2	17	Diabetic nephropathy
KIM-1	17	Acute kidney injury
Notch	10, 17	Renal fibrosis, glomerulosclerosis, diabetic nephropathy
Meprin	10, 17	Acute kidney injury
Klotho	10, 17	Hyperphosphatemia