Table 3.
Comparison of compound properties on PR, RO, RG, PS, PN, and AT.
| Index | PR | RG | RO | PS | PN | AT |
|---|---|---|---|---|---|---|
| MW | 321.68 | 361.52 (165.53) | 442.60 (225.79ˆ##,238.54ˆ*) | 350.48 (163.60,172.94) | 367.95 (244.27,261.78) | 227.44 (140.98ˆ##,149.35ˆ**) |
| MLogP | 2.84 | 0.06 (4.01ˆ##) | 2.44 (3.47,3.82ˆ**) | 1.82 (3.48,3.74ˆ**) | 3.45 (3.44,3.92ˆ**) | 2.99 (2.88,3.25ˆ**) |
| Hdon | 2.42 | 4.61 (3.27ˆ##) | 5.24 (4.08ˆ##,4.28) | 3.22 (2.83,3.26ˆ*) | 3.02 (4.02,4.47ˆ**) | 0.99 (2.55ˆ##,3.22ˆ**) |
| Hacc | 5.14 | 7.88 (5.43ˆ##) | 8.88 (6.35ˆ##,6.40) | 6.45 (5.13,5.27) | 4.76 (6.43,6.93ˆ**) | 2.42 (4.51ˆ##,5.00ˆ**) |
| OB | 32.14 | 27.28 (23.80) | 24.45 (21.79ˆ#,22.53) | 31.13 (22.33,23.92) | 30.08 (21.01,21.83) | 37.97 (20.98ˆ#,22.24ˆ**) |
| DL | 0.3 | 0.32 (0.27) | 0.38 (0.28ˆ#,0.28) | 0.37 (0.28,0.28) | 0.17 (0.26ˆ##,0.26ˆ**) | 0.15 (0.25ˆ##,0.24ˆ**) |
SD, standard deviation; PR, Paeonia lactiflora Pall.; RO, Rheum officinale Baill.; RG, Rehmannia glutinosa (Gaertn.) Li-bosch.; PN, Panax notoginseng (Burk.) F. H. ChenexC. Chow.; PS, Paeonia suffruticosa Andr.; AT, Acorus tatarinowii Schott.; The vital properties include molecular weight (MW); nHAcc, number of acceptor atoms for H-bonds; nHDon, number of donor atoms for H-bonds; DL, drug-likeness; MLogP, Moriguchioctanol–water partition coeff. logP; OB, oralbioavailability. ∗∗p < 0.01, ∗p < 0.05, vs. RG. ##p < 0.01, #p < 0.05, vs. PR.