Table 1. The variance in bleeding criteria definitions (6,32-37).

No.	BARC	TIMI		GUSTO		ISTH		PLATO
0	No bleeding	Minimal	Overt haemorrhage associated with a fall in hemoglobin <3 g/dL (hematocrit of <9%)	Mild	Bleeding that does not meet criteria for either severe or moderate bleeding	Non-clinically relevant minor	Bleeding not requiring intervention/admission	Miniminal	Bleeding not requiring intervention
1	Bleeding is not actionable
2	Any overt, actionable bleed	Minor	Any clinically overt sign of haemorrhage associated with a fall in hemoglobin of 3 to ≤5 g/dL (or hematocrit 9 to ≤5%)	Moderate	Bleeding that requires blood transfusion but does not result in hemodynamic compromise	Clinically relevant minor	Overt bleeding that does not meet the criteria for major criteria, does do require a response in at least one of the following: a hospital admission for bleeding; a physician guided medical or surgical treatment for bleeding; a change in antithrombotic therapy (including interruption or discontinuation of study drug)	Minor	Bleeding requiring medical intervention to stop or treat
3a	Overt bleeding plus hemoglobin drop 3 to <5 g/dL and any transfusion with overt bleeding
3b	Overt bleeding plus hemoglobin drop ≥5 g/dL; includes cardiac tamponade and bleeding requiring surgical intervention or vasoactive agents	Major	Intracranial or clinically significant overt signs of haemorrhage associated with a drop in hemoglobin of >5 g/dL (hematocrit of >15%)	Severe or life-threatening	Intracranial hemorrhage or bleeding that causes hemodynamic compromise and requires intervention	Major	Any of the following: fatal bleeding; symptomatic bleeding in a critical area or organ, such as intracranial, intraspinal, intraocular, retroperitoneal, intraarticular or pericardial, or intramuscular with compartment syndrome; bleeding causing a fall in hemoglobin level of 2 g/dL (1.24 mmol/L) or more, or leading to transfusion of two or more units of whole blood or red cells	Major	Any of the following: significantly disabling hemoglobin drop of 3 to 5 g/dL; requiring transfusion of 2 to 3 units of whole blood or red cells
3c	Intracranial or intraocular bleed compromising vision
4	CABG-related bleeding: perioperative intracranial bleeding within 48 h; reoperation after closure of sternotomy for the purpose of controlling bleeding; transfusion of ≥5 U whole blood or packed red blood cells within 48 h; chest tube output ≥2 L within 24 h							Life-threatening	Any of the following: fatal; intracranial; intrapericardial with cardiac tamponade; resulting in shock requiring vasopressors or surgery; hemoglobin drop of ≥5 g/dL; requiring transfusion of ≥4 units of whole blood or red cells
5	Fatal bleeding