1.

Clinicopathological characteristics and survival analyses of GC patients (N=7,620)

Characteristics	n	5-YSR (%)	χ2	Univariate P value	HR (95% CI)	Multivariate P value
Gender			2.443	0.118	2.227 (2.081−2.376)	0.136
Male	5,378	54.0
Female	2,242	56.0
Age at surgery (year)			82.616	<0.001	1.369 (1.276−1.469)	<0.001
<60	3,986	59.4
≥60	3,634	49.3
Tumor location			320.657	<0.001	0.950 (0.914−0.988)	0.011
Upper third	2,023	49.1			Reference	Reference
Middle third	1,474	52.2			0.761 (0.636−0.911)	0.003
Lower third	3,487	62.9			0.830 (0.730−0.944)	0.004
>2/3 stomach	636	32.4			0.857 (0.744−0.988)	0.034
Tumor size (cm)*			513.623	<0.001	1.345 (1.245−1.452)	<0.001
≤4.0	3,626	68.4
>4.0	3,994	42.2
Lauren classification			90.692	<0.001	1.143 (1.061−1.230)	<0.001
Intestinal	3,215	61.2
Diffuse	4,405	49.8
Type of gastrectomy			439.340	<0.001	0.790 (0.746−0.836)	<0.001
TG	1,741	36.4			Reference	Reference
DG	4,230	63.3			1.288 (1.093−1.518)	0.003
PG	1,649	50.7			0.813 (0.665−0.993)	0.042
pT stage			938.880	<0.001	1.355 (1.303−1.410)	<0.001
T1	945	95.7			Reference	Reference
T2	1,409	67.8			0.122 (0.089−0.167)	<0.001
T3	1,248	53.6			0.527 (0.454−0.612)	<0.001
T4a	3,528	42.4			0.603 (0.524−0.695)	<0.001
T4b	490	26.9			0.726 (0.644−0.818)	<0.001
pN stage			1,829.794	<0.001	1.313 (1.227−1.405)	<0.001
N0	2,793	80.1			Reference	Reference
N1	1,364	58.1			0.177 (0.059−0.532)	0.002
N2	1,487	44.6			0.479 (0.388−0.591)	<0.001
N3a	1,338	27.5			0.524 (0.446−0.615)	<0.001
N3b	638	15.4			0.747 (0.658−0.847)	<0.001
Ratio between metastatic lymph nodes and ELNs (%)			2,036.660	<0.001	1.302 (1.206−1.406)	<0.001
0	2,797	80.0			Reference	Reference
0.1−10.0	1,101	66.0			0.915 (0.306−2.732)	0.874
10.1−40.0	2,037	43.3			0.531 (0.438−0.675)	<0.001
>40.0	1,685	19.5			0.751 (0.674−0.837)	<0.001
ELN count*			13.604	0.001	0.772 (0.726−0.822)	<0.001
<16	2,292	51.7			Reference	Reference
16−30	3,482	55.3			1.630 (1.436−1.851)	<0.001
Table 1 (continued)