Figure 2.

Rigid docking study of the metformin-binding mode to the resveratrol (RESV) binding pocket of SIRT1. Figure shows in sticks all the pharmacophoric interaction residues involved in the in silico binding of metformin to the RESV binding pocket of SIRT1, using PLIP. The main residues involved in silibinin interaction with the protein backbone are shown in black; the residue numbers shown correspond to the original PDB file numbering.