Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding modes of metformin to SIRT1. Global view of the human SIRT1 structure showing the location of the metformin binding sites: (1) metformin poses (4KXQ, 4IF6, 4I5I, and 4ZZJ) at the NAD+ binding site, specifically the indole nucleus; (2) metformin poses (4ZZI) at a cavity between the NAD+ binding site and the one occupied by the indole derivative (SIRT1 inhibitor) 4I5; and (3) metformin pose at the resveratrol binding pocket at the amino-terminal activation domain of SIRT1.
