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. 2018 Nov 6;9:2578. doi: 10.3389/fimmu.2018.02578

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Copyright © 2018 Edwards, de Oca, de Labastida Rivera, Kumar, Ng, Wang, Amante, Kometani, Kurosaki, Sidwell, Kallies and Engwerda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T cell-specific BACH2 influences tissue-specific expansion of antigen experienced CD4⁺ T cells following L. donovani infection. (A) Gating strategy for CD4⁺ T, CD8⁺ T, and antigen-experienced (CD49d⁺ CD11a⁺) CD4⁺ T cells in the spleen (B,C) and liver (D,E) of B6.Bach2^ΔT (open triangles) and B6.Bach2^fl/fl (closed circles) mice infected with L. donovan at 0, 14, and 28 days p.i., The numbers (B,D) and frequencies (C,E) of CD4⁺ T, CD8⁺ T, and antigen-experienced CD4⁺ T cells, as indicated, were measured by flow cytometry. n = 4–7 mice per time point, mean ± SEM, **P < 0.01, ***P < 0.001 significance assessed by Mann-Whitney U-test.