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Increased CSF levels of glutamate (A), glutamine (B) and glutamate/glutamine ratio (C) in patients with probable AD and major depression. Symbols correspond to individual subjects. Horizontal lines represent mean values for each group. Statistical significances assessed by one-way ANOVA followed by Bonferroni adjustment for multiple comparisons. *P < 0.05; ***P < 0.001. AD, probable Alzheimer's disease; Ctrl, healthy controls; MDD, major depressive disorder; Hydro, hydrocephalus.
