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In vitro study to determine whether HCMV IE1 protected hPML from degradation by ICP0. (A) Diagram of the mutants of HCMV IE1. (B) Purified HCMV IE1 or its mutants were incubated with HeLa cell nuclear extracts for 30 min at 37°C. Purified ICP0 was then added or not added to the reaction mix, which was incubated for another 30 min. Western blot assay was then performed to detect PML, ICP0, IE1, and lamin A.
